Assay Detail
Functional
CHEMBL1176124
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Antiproliferative activity against human HCC827 cells after 96 hrs by MTS assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC827 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.36 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1172843 | — | — | 1 | 8.10 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 8.10 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.92 |
| CHEMBL1172773 | — | — | 1 | 6.41 |
| CHEMBL1172781 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1172843 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL939 | GEFITINIB | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1172773 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL1172781 | — | IC50 | = | 518.0 | nM | 6.29 |