Assay Detail
Functional
CHEMBL1176162
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Antiviral activity against HIV1 infected in human H9 cells after 4 days by p24 antigen ELISA
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.89 | 5.35 |
| EC50 | 1 | 5.85 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 5.85 |
| CHEMBL273330 | — | — | 1 | 5.35 |
| CHEMBL404519 | BEVIRIMAT | 2.0 | 1 | 5.16 |
| CHEMBL263957 | — | — | 1 | 4.93 |
| CHEMBL1171266 | — | — | 1 | 4.89 |
| CHEMBL446317 | — | — | 1 | 4.80 |
| CHEMBL7365 | — | — | 1 | 4.80 |
| CHEMBL448637 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269277 | BETULINIC ACID | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL273330 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL404519 | BEVIRIMAT | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL263957 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL1171266 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL446317 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL7365 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL448637 | — | IC50 | = | 48000.0 | nM | 4.32 |