Assay Detail
Binding
CHEMBL1176239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8OH-DPAT from 5HT1A receptor in rat CRL:CD(SD)BR-COBS hippocampus by scintillation spectrometry
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.81 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173143 | — | — | 1 | 9.00 |
| CHEMBL1173018 | — | — | 1 | 8.70 |
| CHEMBL1172205 | — | — | 1 | 8.52 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 8.25 |
| CHEMBL1172206 | — | — | 1 | 8.10 |
| CHEMBL1171824 | — | — | 1 | 8.10 |
| CHEMBL1173077 | — | — | 1 | 7.96 |
| CHEMBL496739 | — | — | 1 | 7.92 |
| CHEMBL1171823 | — | — | 1 | 7.80 |
| CHEMBL1171644 | — | — | 1 | 7.80 |
| CHEMBL1172734 | — | — | 1 | 7.72 |
| CHEMBL1171646 | — | — | 1 | 7.52 |
| CHEMBL1172204 | — | — | 1 | 7.32 |
| CHEMBL1173017 | — | — | 1 | 7.31 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.80 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 6.21 |
| CHEMBL1173142 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173143 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1173018 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1172205 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL1172206 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL1171824 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL1173077 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL496739 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL1171823 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1171644 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1172734 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1171646 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1172204 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL1173017 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL42 | CLOZAPINE | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL715 | OLANZAPINE | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL1173142 | — | Ki | - | — | - |