Assay Detail
Binding
CHEMBL1176720
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human plasma BChE pretreated for 30 mins by Ellman technique
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.60 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54577 | — | — | 1 | 8.22 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.80 |
| CHEMBL1173624 | — | — | 1 | 7.37 |
| CHEMBL417915 | — | — | 1 | 7.29 |
| CHEMBL1173090 | — | — | 1 | 7.29 |
| CHEMBL211471 | NEOSTIGMINE METHYLSULFATE | 4.0 | 1 | 7.22 |
| CHEMBL1173604 | — | — | 1 | 6.89 |
| CHEMBL1172913 | — | — | 1 | 6.85 |
| CHEMBL1173605 | — | — | 1 | 6.68 |
| CHEMBL1173603 | — | — | 1 | 6.26 |
| CHEMBL812 | PYRIDOSTIGMINE BROMIDE | 4.0 | 1 | 6.05 |
| CHEMBL54727 | — | — | 1 | 5.81 |
| CHEMBL300143 | — | — | 1 | 5.71 |
| CHEMBL1171854 | — | — | 1 | 4.75 |
| CHEMBL1172830 | — | — | 1 | 4.75 |
| CHEMBL1173543 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54577 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1173624 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL417915 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1173090 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL211471 | NEOSTIGMINE METHYLSULFATE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1173604 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1172913 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1173605 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1173603 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL812 | PYRIDOSTIGMINE BROMIDE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL54727 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL300143 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL1171854 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1172830 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1173543 | — | IC50 | > | 30000.0 | nM | - |