Assay Detail
Functional
CHEMBL1176728
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT-2 cells assessed as inhibition of viral-mediated cell death after 5 days by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
[d4U]-spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.04 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240416 | — | — | 1 | 7.38 |
| CHEMBL1173828 | — | — | 1 | 6.60 |
| CHEMBL1172574 | — | — | 1 | 5.89 |
| CHEMBL1172575 | — | — | 1 | 5.72 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 5.64 |
| CHEMBL1172577 | — | — | 1 | 5.54 |
| CHEMBL1172576 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240416 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1173828 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1172574 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1172575 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL991 | STAVUDINE | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1172577 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1172576 | — | EC50 | = | 3100.0 | nM | 5.51 |