Assay Detail
Functional
CHEMBL1176809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Molt4/C8 cells after 2 days by coulter counting
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.12 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227027 | — | — | 1 | 8.07 |
| CHEMBL227987 | — | — | 1 | 8.00 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.80 |
| CHEMBL1172941 | — | — | 1 | 7.75 |
| CHEMBL1171846 | — | — | 1 | 7.75 |
| CHEMBL1171666 | — | — | 1 | 7.57 |
| CHEMBL1173006 | — | — | 1 | 7.55 |
| CHEMBL1173437 | — | — | 1 | 7.25 |
| CHEMBL1171493 | — | — | 1 | 7.12 |
| CHEMBL1173439 | — | — | 1 | 7.03 |
| CHEMBL1171667 | — | — | 1 | 7.03 |
| CHEMBL1170869 | — | — | 1 | 6.37 |
| CHEMBL1170872 | — | — | 1 | 6.36 |
| CHEMBL1171979 | — | — | 1 | 6.30 |
| CHEMBL1171665 | — | — | 1 | 6.26 |
| CHEMBL1171664 | — | — | 1 | 5.68 |
| CHEMBL228167 | — | — | 1 | - |
| CHEMBL228054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227027 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL227987 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1172941 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1171846 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1171666 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1173006 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1173437 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1171493 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1173439 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL1171667 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1170869 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1170872 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1171979 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1171665 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1171664 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL228167 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL228054 | — | IC50 | > | 10000.0 | nM | - |