Assay Detail
Binding
CHEMBL1177097
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Inhibition of Stenotrophomonas maltophilia beta lactamase L1 in presence of Zn+ chelator
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Stenotrophomonas maltophilia |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.30 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173797 | — | — | 1 | 6.40 |
| CHEMBL1173800 | — | — | 1 | 6.16 |
| CHEMBL1173799 | — | — | 1 | 5.77 |
| CHEMBL1170425 | — | — | 1 | 5.40 |
| CHEMBL1173798 | — | — | 1 | 5.40 |
| CHEMBL1173336 | — | — | 1 | 4.92 |
| CHEMBL1173337 | — | — | 1 | 4.85 |
| CHEMBL1170023 | DIISOPROPYL MERCAPTO(PHENYL)METHYLPHOSPHONATE | — | 1 | 4.80 |
| CHEMBL1172743 | — | — | 1 | 4.75 |
| CHEMBL1170424 | — | — | 1 | 4.50 |
| CHEMBL1172387 | — | — | 1 | - |
| CHEMBL1173338 | — | — | 1 | - |
| CHEMBL1173339 | — | — | 1 | - |
| CHEMBL1172388 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173797 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL1173800 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL1173799 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL1170425 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL1173798 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL1173336 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL1173337 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL1170023 | DIISOPROPYL MERCAPTO(PHENYL)METHYLPHOSPHONATE | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL1172743 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL1170424 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL1172387 | — | Ki | > | 250000.0 | nM | - |
| CHEMBL1173338 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL1173339 | — | Ki | > | 40000.0 | nM | - |
| CHEMBL1172388 | — | Ki | > | 40000.0 | nM | - |