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Assay Detail

CHEMBL1177271

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of 5(6)-FAM-mannoside from Escherichia coli FimH by fluorescence polarization assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Structure-based drug design and optimization of mannoside bacterial FimH antagonists.
Han Z, Pinkner JS, Ford B, Obermann R, Nolan W, Wildman SA, Hobbs D, Ellenberger T, Cusumano CK, Hultgren SJ, Janetka JW.
J Med Chem (2010) 53 : 4779 -4792
PubMed 20507142 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 7.03 7.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1172750 1 7.36
CHEMBL1171277 1 7.28
CHEMBL1171278 1 7.23
CHEMBL1170259 1 7.19
CHEMBL1172857 1 7.16
CHEMBL1172856 1 7.12
CHEMBL1170269 1 7.11
CHEMBL1170079 1 7.11
CHEMBL1172931 1 7.08
CHEMBL1170270 1 7.06
CHEMBL1170455 1 7.05
CHEMBL1172749 1 7.04
CHEMBL1171651 1 7.01
CHEMBL1172588 1 7.00
CHEMBL1172858 1 6.94
CHEMBL1173356 1 6.91
CHEMBL1173060 1 6.80
CHEMBL1172997 1 6.79
CHEMBL1170453 1 6.73
CHEMBL1170454 BUTYLALPHAMAN 1 6.61

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1172750 EC50 = 44.0 nM 7.36
CHEMBL1171277 EC50 = 52.0 nM 7.28
CHEMBL1171278 EC50 = 59.0 nM 7.23
CHEMBL1170259 EC50 = 64.0 nM 7.19
CHEMBL1172857 EC50 = 70.0 nM 7.16
CHEMBL1172856 EC50 = 75.0 nM 7.12
CHEMBL1170269 EC50 = 77.0 nM 7.11
CHEMBL1170079 EC50 = 78.0 nM 7.11
CHEMBL1172931 EC50 = 84.0 nM 7.08
CHEMBL1170270 EC50 = 87.0 nM 7.06
CHEMBL1170455 EC50 = 89.0 nM 7.05
CHEMBL1172749 EC50 = 91.0 nM 7.04
CHEMBL1171651 EC50 = 97.0 nM 7.01
CHEMBL1172588 EC50 = 99.0 nM 7.00
CHEMBL1172858 EC50 = 114.0 nM 6.94
CHEMBL1173356 EC50 = 122.0 nM 6.91
CHEMBL1173060 EC50 = 160.0 nM 6.80
CHEMBL1172997 EC50 = 162.0 nM 6.79
CHEMBL1170453 EC50 = 187.0 nM 6.73
CHEMBL1170454 BUTYLALPHAMAN EC50 = 245.0 nM 6.61