Assay Detail
Functional
CHEMBL1177506
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Phototoxicity against human sNCTC-2544 cells irradiated with 3.75 J/cm'2 after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCTC-2544 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of pyrrolo[3,2-h]quinolinones with good photochemotherapeutic activity and no DNA damage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.67 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53569 | ANGELICIN | — | 1 | 6.05 |
| CHEMBL1173675 | — | — | 1 | 6.00 |
| CHEMBL1173674 | — | — | 1 | 5.96 |
| CHEMBL1173551 | — | — | 1 | 5.80 |
| CHEMBL1173676 | — | — | 1 | 5.66 |
| CHEMBL1173459 | — | — | 1 | 5.58 |
| CHEMBL1173460 | — | — | 1 | 5.57 |
| CHEMBL1173257 | — | — | 1 | 5.26 |
| CHEMBL1173461 | — | — | 1 | 5.14 |
| CHEMBL1173554 | — | — | 1 | - |
| CHEMBL1173186 | — | — | 1 | - |
| CHEMBL1173187 | — | — | 1 | - |
| CHEMBL1173188 | — | — | 1 | - |
| CHEMBL1173392 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53569 | ANGELICIN | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1173675 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1173674 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1173551 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1173676 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1173459 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1173460 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1173257 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1173461 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1173554 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1173186 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1173187 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1173188 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1173392 | — | IC50 | > | 20000.0 | nM | - |