Assay Detail
Binding
CHEMBL1211147
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum FabI
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Enoyl-acyl-carrier protein reductase (CHEMBL4150) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.01 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129451 | (-)-CATECHINGALLATE | — | 1 | 6.52 |
| CHEMBL31574 | FISETIN | 2.0 | 1 | 6.00 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.82 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129451 | (-)-CATECHINGALLATE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL31574 | FISETIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL50 | QUERCETIN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 2000.0 | nM | 5.70 |