Assay Detail
Binding
CHEMBL1211419
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Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetry
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 6.10 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | 4.0 | 1 | 6.89 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.46 |
| CHEMBL1210322 | — | — | 1 | 6.44 |
| CHEMBL1210959 | — | — | 1 | 6.44 |
| CHEMBL1210876 | — | — | 1 | 6.44 |
| CHEMBL1209944 | — | — | 1 | 6.42 |
| CHEMBL1210418 | — | — | 1 | 6.39 |
| CHEMBL1209943 | — | — | 1 | 6.38 |
| CHEMBL1210416 | — | — | 1 | 6.29 |
| CHEMBL1210963 | — | — | 1 | 6.28 |
| CHEMBL1210319 | — | — | 1 | 6.28 |
| CHEMBL1210321 | — | — | 1 | 6.16 |
| CHEMBL1210962 | — | — | 1 | 6.16 |
| CHEMBL1210320 | — | — | 1 | 6.16 |
| CHEMBL1210419 | — | — | 1 | 6.14 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 6.12 |
| CHEMBL1210818 | — | — | 1 | 6.06 |
| CHEMBL1210184 | — | — | 1 | 5.92 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.85 |
| CHEMBL1210879 | — | — | 1 | 5.80 |
| CHEMBL1210420 | — | — | 1 | 5.79 |
| CHEMBL1210880 | — | — | 1 | 5.78 |
| CHEMBL1210253 | — | — | 1 | 5.77 |
| CHEMBL1210066 | — | — | 1 | 5.71 |
| CHEMBL130441 | — | — | 1 | 5.40 |
| CHEMBL1210877 | — | — | 1 | 5.17 |
| CHEMBL1210249 | — | — | 1 | - |
| CHEMBL1210187 | — | — | 1 | - |
| CHEMBL1210250 | — | — | 1 | - |
| CHEMBL1210251 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL61 | PODOFILOX | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1210959 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1210876 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1210322 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1209944 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1210418 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1209943 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1210416 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1210963 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1210319 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1210321 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1210962 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1210320 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1210419 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1210818 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1210184 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1210879 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1210420 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL1210880 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL1210253 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1210066 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL130441 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1210877 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1210819 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL131667 | — | IC50 | - | — | - | |
| CHEMBL129939 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL335282 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | - | — | - | |
| CHEMBL1210123 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL1210124 | — | IC50 | - | — | - | |
| CHEMBL338715 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1210185 | — | IC50 | - | — | - | |
| CHEMBL1210186 | — | IC50 | - | — | - | |
| CHEMBL130560 | — | IC50 | - | — | - | |
| CHEMBL1210188 | — | IC50 | - | — | - | |
| CHEMBL1210249 | — | IC50 | - | — | - | |
| CHEMBL1210878 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL1210417 | — | IC50 | - | — | - | |
| CHEMBL1210323 | — | IC50 | - | — | - | |
| CHEMBL1210960 | — | IC50 | - | — | - | |
| CHEMBL1210961 | — | IC50 | - | — | - | |
| CHEMBL1209941 | — | IC50 | - | — | - | |
| CHEMBL1209942 | — | IC50 | - | — | - | |
| CHEMBL1210252 | — | IC50 | - | — | - | |
| CHEMBL1210251 | — | IC50 | - | — | - | |
| CHEMBL1210250 | — | IC50 | - | — | - | |
| CHEMBL1210187 | — | IC50 | - | — | - |