Assay Detail
Functional
CHEMBL1211420
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Antiproliferative activity against human KB/HeLa cells after 48 hrs by XTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.22 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.00 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.52 |
| CHEMBL1210959 | — | — | 1 | 6.89 |
| CHEMBL1210876 | — | — | 1 | 6.85 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL107 | COLCHICINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1210959 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1210876 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 140.0 | nM | 6.85 |