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Assay Detail

CHEMBL1211754

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of alpha glucosidase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Docking and SAR studies of salacinol derivatives as alpha-glucosidase inhibitors.
Nakamura S, Takahira K, Tanabe G, Morikawa T, Sakano M, Ninomiya K, Yoshikawa M, Muraoka O, Nakanishi I.
Bioorg Med Chem Lett (2010) 20 : 4420 -4423
PubMed 20598536 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 5.19 5.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1208974 SALACINOL 1 5.28
CHEMBL1684162 NEOSALACINOL 1 5.10
CHEMBL1209027 SALAPRINOL 1 -
CHEMBL1209028 1 -
CHEMBL1209029 1 -
CHEMBL1209030 1 -
CHEMBL1209031 1 -
CHEMBL1209032 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1208974 SALACINOL IC50 = 5248.07 nM 5.28
CHEMBL1684162 NEOSALACINOL IC50 = 7943.28 nM 5.10
CHEMBL1209027 SALAPRINOL IC50 = 1000000.0 nM -
CHEMBL1209028 IC50 > 1000000.0 nM -
CHEMBL1209029 IC50 > 1000000.0 nM -
CHEMBL1209030 IC50 > 1000000.0 nM -
CHEMBL1209031 IC50 > 1000000.0 nM -
CHEMBL1209032 IC50 = 114815.36 nM -