Compound Detail
CHEMBL1209027
SALAPRINOL Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1209027 |
| Name | SALAPRINOL |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WBUXSJSEIMPRAS-KETUFZKJSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
304.3
MW (Da)
-3.46
ALogP
8
HBA
4
HBD
147.3
PSA (Ų)
0.22
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal CHEMBL3114 | IC50 | 6.54 | 5.6467 | 290.0 | 3 |
| Acidic alpha-glucosidase CHEMBL3513 | IC50 | 5.5 | 5.5 | 3200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sucrase-isomaltase, intestinal | IC50 | = | 290.0 | nM | 6.54 | Inhibition of rat small intestinal sucrase after 30 mins | 21420866 |
| Sucrase-isomaltase, intestinal | IC50 | = | 2600.0 | nM | 5.58 | Inhibition of rat small intestinal isomaltase after 30 mins | 21420866 |
| Acidic alpha-glucosidase | IC50 | = | 3200.0 | nM | 5.5 | Inhibition of rat small intestinal maltase after 30 mins | 21420866 |
| Sucrase-isomaltase, intestinal | IC50 | = | 15000.0 | nM | 4.82 | Inhibition of rat intestinal isomaltase | 21345683 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21345683 | 10.1016/j.bmc.2011.01.052 | Sucrase-isomaltase, intestinal | 3 |
| 21345683 | 10.1016/j.bmc.2011.01.052 | Acidic alpha-glucosidase | 2 |
| 21420866 | 10.1016/j.bmc.2011.02.028 | Sucrase-isomaltase, intestinal | 2 |
| 20598536 | 10.1016/j.bmcl.2010.06.059 | Unchecked | 1 |
| 21420866 | 10.1016/j.bmc.2011.02.028 | Acidic alpha-glucosidase | 1 |
Data from ChEMBL 36 via Core Engine