Assay Detail
Binding
CHEMBL1767943
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat small intestinal maltase after 30 mins
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.44 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476960 | VOGLIBOSE | 4.0 | 1 | 6.70 |
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | 5.77 |
| CHEMBL1209027 | SALAPRINOL | — | 1 | 5.50 |
| CHEMBL1208974 | SALACINOL | — | 1 | 5.28 |
| CHEMBL1093264 | KOTALANOL | — | 1 | 5.14 |
| CHEMBL1765343 | — | — | 1 | 4.24 |
| CHEMBL1765290 | — | — | 1 | - |
| CHEMBL1258528 | PONKORANOL | — | 1 | - |
| CHEMBL1765289 | — | — | 1 | - |
| CHEMBL1765344 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476960 | VOGLIBOSE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL404271 | ACARBOSE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1209027 | SALAPRINOL | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1208974 | SALACINOL | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL1093264 | KOTALANOL | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1765343 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL1765290 | — | IC50 | > | 236000.0 | nM | - |
| CHEMBL1258528 | PONKORANOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL1765289 | — | IC50 | > | 236000.0 | nM | - |
| CHEMBL1765344 | — | IC50 | > | 236000.0 | nM | - |