Assay Detail
Binding
CHEMBL1211829
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Inhibition of human recombinant carbonic anhydrase 7 after 15 mins by stopped-flow CO2 hydration assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.67 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.60 |
| CHEMBL71611 | — | — | 1 | 8.54 |
| CHEMBL265674 | — | — | 1 | 8.28 |
| CHEMBL352535 | — | — | 1 | 7.82 |
| CHEMBL1209038 | — | — | 1 | 7.46 |
| CHEMBL1209039 | — | — | 1 | 7.32 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL71611 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL265674 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL352535 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1209038 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL1209039 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL118 | CELECOXIB | Ki | = | 2170.0 | nM | 5.66 |