Assay Detail
Binding
CHEMBL1211897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LuxR-dependent quorum sensing in Vibrio fischeri assessed as reduction of 3-oxo-C6-HSL-induced bioluminescence intensity
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aliivibrio fischeri |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transcriptional activator protein LuxR (CHEMBL5351) ↗| Type | SINGLE PROTEIN |
| Organism | Aliivibrio fischeri |
Publication
LuxR-dependent quorum sensing: computer aided discovery of new inhibitors structurally unrelated to N-acylhomoserine lactones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.41 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1208858 | CALMIDAZOLIUM CHLORIDE | — | 1 | 5.16 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 4.57 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 4.40 |
| CHEMBL152408 | PIMETHIXENE | 2.0 | 1 | 4.25 |
| CHEMBL17157 | TERFENADINE | 4.0 | 1 | 4.04 |
| CHEMBL254832 | FENDILINE | 2.0 | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1208858 | CALMIDAZOLIUM CHLORIDE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL809 | SERTRALINE | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL152408 | PIMETHIXENE | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL17157 | TERFENADINE | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL254832 | FENDILINE | IC50 | = | 91000.0 | nM | 4.04 |