Assay Detail

CHEMBL1216341

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Binding

Inhibition of calcineurin phosphatase activity of CyPA

ChEMBL ↗

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Target

Peptidyl-prolyl cis-trans isomerase A (CHEMBL1949) ↗

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Peptidyl-prolyl cis-trans isomerase A (CHEMBL1949) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Peptidyl-prolyl cis-trans isomerase A

CHEMBL1949

Anchored from Assay target.

Protein identity Peptidyl-prolyl cis-trans isomerase A

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Peptidyl-prolyl cis-trans isomerase A (CHEMBL1949) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro.

Hopkins S, Scorneaux B, Huang Z, Murray MG, Wring S, Smitley C, Harris R, Erdmann F, Fischer G, Ribeill Y.
Antimicrob Agents Chemother (2010) 54 : 660 -672
PubMed 19933795 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	8.66	8.73

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1269597	SCY 635	2.0	1	8.73
CHEMBL160	CYCLOSPORINE	4.0	1	8.58

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1269597	SCY 635	Ki	=	1.84	nM	8.73
CHEMBL160	CYCLOSPORINE	Ki	=	2.64	nM	8.58