Compound Detail
CHEMBL1269597
SCY 635 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)[C@H](SCCN(C)C)C(=O)N(C)[C@@H](CC(C)(C)O)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
Basic Information
| ChEMBL ID | CHEMBL1269597 |
| Name | SCY 635 |
| Phase | Phase II |
| Structure Type | BOTH |
| InChI Key | AQHMBDAHQGYLIU-XNFHFXFQSA-N |
11
Targets
33
Activities
4
Assay Types
30
PK Parameters
20
Publications
2
Known Names
2
Indications
1
Mechanisms
Molecular Properties
1321.8
MW (Da)
Drug Information
| Molecule Type | Protein |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Cyclophilin A inhibitor | INHIBITOR | Peptidyl-prolyl cis-trans isomerase A | ✓ | ✓ |
Indications
Hepatitis C Hepatitis C, Chronic
Activity Summary
EC50 21 meas. best 7.35
IC50 8 meas. best 8.02
Kd 3 meas. best 8.54
Ki 1 meas. best 8.73
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Peptidyl-prolyl cis-trans isomerase A CHEMBL1949 | Ki | 8.73 | 8.73 | 1.8 | 1 |
| Peptidyl-prolyl cis-trans isomerase B CHEMBL2075 | Kd | 8.54 | 8.54 | 2.9 | 1 |
| Peptidyl-prolyl cis-trans isomerase F, mitochondrial CHEMBL3325306 | Kd | 8.51 | 8.51 | 3.1 | 1 |
| Peptidyl-prolyl cis-trans isomerase A CHEMBL1949 | Kd | 8.49 | 8.49 | 3.2 | 1 |
| Peptidyl-prolyl cis-trans isomerase A CHEMBL1949 | IC50 | 8.02 | 6.915 | 9.5 | 2 |
| Peptidyl-prolyl cis-trans isomerase B CHEMBL2075 | IC50 | 7.99 | 7.99 | 10.3 | 1 |
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 7.35 | 7.35 | 45.0 | 1 |
| Human immunodeficiency virus 1 CHEMBL378 | EC50 | 7.35 | 7.35 | 45.0 | 1 |
| Hepatitis C virus CHEMBL379 | EC50 | 7.3 | 6.9006 | 50.0 | 17 |
| Jurkat CHEMBL397 | EC50 | 5.38 | 5.19 | 4209.0 | 2 |
| PBMC CHEMBL613107 | IC50 | 5.33 | 5.33 | 4700.0 | 1 |
| PBMC CHEMBL613107 | EC50 | 5.28 | 5.28 | 5300.0 | 1 |
| Cytochrome P450 2C19 CHEMBL3622 | IC50 | 4.91 | 4.91 | 12400.0 | 1 |
| Cytochrome P450 2C9 CHEMBL3397 | IC50 | 4.87 | 4.87 | 13400.0 | 1 |
| Cytochrome P450 3A4 CHEMBL340 | IC50 | 4.23 | 4.23 | 58500.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 22500.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 37300.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 49900.0 | ng.hr.mL-1 | Macaca mulatta |
| AUC | 31500.0 | ng.hr.mL-1 | Macaca mulatta |
| AUC | 13000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 26500.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 42500.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 27900.0 | ng.hr.mL-1 | Macaca mulatta |
| AUC | 59200.0 | ng.hr.mL-1 | Macaca mulatta |
| AUC | 42000.0 | ng.hr.mL-1 | Macaca mulatta |
| AUC | 139000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 120000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 141000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 30500.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 18000.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 30200.0 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 4.6 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 6.7 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 4.7 | ng.hr.mL-1 | Rattus norvegicus |
| CL | 9000.0 | mL.min-1.g-1 | Mus musculus |
| CL | 14000.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 1.48 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 2.233 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 0.47 | mL.min-1.kg-1 | Macaca mulatta |
| CL | 0.5283 | mL.min-1.kg-1 | Macaca mulatta |
| Cmax | 1142.36 | nM | Rattus norvegicus |
| Cmax | 2262.03 | nM | Rattus norvegicus |
| Cmax | 1747.59 | nM | Macaca mulatta |
| Cmax | 1936.72 | nM | Macaca mulatta |
| Cmax | 680.88 | nM | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine