Assay Detail
Binding
CHEMBL802760
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against HIV-1 RT in CEM4 cell line
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis of non-immunosuppressive cyclophilin-Binding cyclosporin A derivatives as potential anti-HIV-1 drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.24 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2407581 | — | — | 1 | 8.60 |
| CHEMBL3038082 | — | — | 1 | 7.71 |
| CHEMBL3038084 | — | — | 1 | 7.71 |
| CHEMBL3038085 | — | — | 1 | 7.62 |
| CHEMBL3038081 | — | — | 1 | 7.46 |
| CHEMBL3038083 | — | — | 1 | 7.37 |
| CHEMBL1269597 | SCY 635 | 2.0 | 1 | 7.35 |
| CHEMBL3038090 | — | — | 1 | 7.33 |
| CHEMBL3038087 | — | — | 1 | 7.18 |
| CHEMBL3038089 | — | — | 1 | 7.16 |
| CHEMBL3038088 | — | — | 1 | 7.14 |
| CHEMBL3038086 | — | — | 1 | 7.10 |
| CHEMBL3038092 | — | — | 1 | 7.09 |
| CHEMBL2407585 | — | — | 1 | 7.08 |
| CHEMBL405301 | — | — | 1 | 7.02 |
| CHEMBL3038093 | — | — | 1 | 7.00 |
| CHEMBL442519 | — | — | 1 | 6.86 |
| CHEMBL3038091 | — | — | 1 | 6.53 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2407581 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3038082 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL3038084 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL3038085 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3038081 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3038083 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1269597 | SCY 635 | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3038090 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3038087 | — | IC50 | = | 65.5 | nM | 7.18 |
| CHEMBL3038089 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3038088 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL3038086 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3038092 | — | IC50 | = | 80.5 | nM | 7.09 |
| CHEMBL2407585 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL405301 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3038093 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL442519 | — | IC50 | = | 137.5 | nM | 6.86 |
| CHEMBL3038091 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 455.0 | nM | 6.34 |