Assay Detail

CHEMBL3389005

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to human cyclophilin B by surface plasmon resonance method

ChEMBL ↗

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Target

Peptidyl-prolyl cis-trans isomerase B (CHEMBL2075) ↗

Open DB target context

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Peptidyl-prolyl cis-trans isomerase B (CHEMBL2075) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Peptidyl-prolyl cis-trans isomerase B

CHEMBL2075

Anchored from Assay target.

Protein identity Peptidyl-prolyl cis-trans isomerase B

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Peptidyl-prolyl cis-trans isomerase B (CHEMBL2075) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.

Fu J, Tjandra M, Becker C, Bednarczyk D, Capparelli M, Elling R, Hanna I, Fujimoto R, Furegati M, Karur S, Kasprzyk T, Knapp M, Leung K, Li X, Lu P, Mergo W, Miault C, Ng S, Parker D, Peng Y, Roggo S, Rivkin A, Simmons RL, Wang M, Wiedmann B, Weiss AH, Xiao L, Xie L, Xu W, Yifru A, Yang S, Zhou B, Sweeney ZK.
J Med Chem (2014) 57 : 8503 -8516
PubMed 25310383 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	4	8.65	9.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1651956	ALISPORIVIR	3.0	1	9.00
CHEMBL3344501	—	—	1	8.92
CHEMBL1269597	SCY 635	2.0	1	8.54
CHEMBL1688529	NIM811	2.0	1	8.13

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1651956	ALISPORIVIR	Kd	=	1.0	nM	9.00
CHEMBL3344501	—	Kd	=	1.2	nM	8.92
CHEMBL1269597	SCY 635	Kd	=	2.9	nM	8.54
CHEMBL1688529	NIM811	Kd	=	7.4	nM	8.13