Assay Detail
Functional
CHEMBL1273326
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Antiviral activity against HCV after 72 hrs by stable luciferase reporter gene assay
40
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.69 | 7.40 |
| EC90 | 20 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1269583 | — | — | 2 | 7.40 |
| CHEMBL1269597 | SCY 635 | 2.0 | 2 | 7.30 |
| CHEMBL1269584 | — | — | 2 | 7.00 |
| CHEMBL1269581 | — | — | 2 | 6.92 |
| CHEMBL1269580 | — | — | 2 | 6.85 |
| CHEMBL1269592 | — | — | 2 | 6.85 |
| CHEMBL1269591 | — | — | 2 | 6.85 |
| CHEMBL1269595 | — | — | 2 | 6.82 |
| CHEMBL1269582 | — | — | 2 | 6.80 |
| CHEMBL1269594 | — | — | 2 | 6.77 |
| CHEMBL1269590 | — | — | 2 | 6.77 |
| CHEMBL1269596 | — | — | 2 | 6.75 |
| CHEMBL1269589 | — | — | 2 | 6.72 |
| CHEMBL1269579 | — | — | 2 | 6.70 |
| CHEMBL1269585 | — | — | 2 | 6.52 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 2 | 6.43 |
| CHEMBL1269593 | — | — | 2 | 6.42 |
| CHEMBL1269586 | — | — | 2 | 6.18 |
| CHEMBL1269588 | — | — | 2 | 6.00 |
| CHEMBL1269587 | — | — | 2 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1269583 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1269597 | SCY 635 | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1269584 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1269581 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1269580 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1269592 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1269591 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1269595 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1269582 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1269594 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1269590 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1269596 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1269589 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1269579 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1269585 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL160 | CYCLOSPORINE | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1269593 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1269586 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL1269588 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1269587 | — | EC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL1269579 | — | EC90 | = | 480.0 | nM | - |
| CHEMBL1269580 | — | EC90 | = | 360.0 | nM | - |
| CHEMBL1269581 | — | EC90 | = | 310.0 | nM | - |
| CHEMBL1269582 | — | EC90 | = | 300.0 | nM | - |
| CHEMBL1269583 | — | EC90 | = | 140.0 | nM | - |
| CHEMBL1269584 | — | EC90 | = | 270.0 | nM | - |
| CHEMBL1269585 | — | EC90 | = | 820.0 | nM | - |
| CHEMBL1269586 | — | EC90 | = | 2350.0 | nM | - |
| CHEMBL1269587 | — | EC90 | = | 6740.0 | nM | - |
| CHEMBL1269588 | — | EC90 | = | 2850.0 | nM | - |
| CHEMBL1269589 | — | EC90 | = | 670.0 | nM | - |
| CHEMBL1269590 | — | EC90 | = | 300.0 | nM | - |
| CHEMBL1269591 | — | EC90 | = | 380.0 | nM | - |
| CHEMBL1269592 | — | EC90 | = | 300.0 | nM | - |
| CHEMBL1269593 | — | EC90 | = | 950.0 | nM | - |
| CHEMBL1269594 | — | EC90 | = | 350.0 | nM | - |
| CHEMBL1269595 | — | EC90 | = | 370.0 | nM | - |
| CHEMBL1269596 | — | EC90 | = | 530.0 | nM | - |
| CHEMBL160 | CYCLOSPORINE | EC90 | = | 910.0 | nM | - |
| CHEMBL1269597 | SCY 635 | EC90 | = | 240.0 | nM | - |