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Assay Detail

CHEMBL1273324

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to cyclophilin B by ELISA
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Peptidyl-prolyl cis-trans isomerase B (CHEMBL2075)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents.
Scribner A, Houck D, Huang Z, Mosier S, Peel M, Scorneaux B.
Bioorg Med Chem Lett (2010) 20 : 6542 -6546
PubMed 20943390 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.41 8.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL160 CYCLOSPORINE 4.0 1 8.06
CHEMBL1269583 1 8.03
CHEMBL1269597 SCY 635 2.0 1 7.99
CHEMBL1269588 1 7.90
CHEMBL1269595 1 7.76
CHEMBL1269596 1 7.70
CHEMBL1269582 1 7.69
CHEMBL1269584 1 7.62
CHEMBL1269589 1 7.60
CHEMBL1269580 1 7.58
CHEMBL1269591 1 7.54
CHEMBL1269581 1 7.52
CHEMBL1269594 1 7.25
CHEMBL1269590 1 7.22
CHEMBL1269579 1 7.17
CHEMBL1269585 1 7.10
CHEMBL1269592 1 7.01
CHEMBL1269586 1 6.82
CHEMBL1269593 1 6.80
CHEMBL1269587 1 5.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL160 CYCLOSPORINE IC50 = 8.78 nM 8.06
CHEMBL1269583 IC50 = 9.45 nM 8.03
CHEMBL1269597 SCY 635 IC50 = 10.3 nM 7.99
CHEMBL1269588 IC50 = 12.7 nM 7.90
CHEMBL1269595 IC50 = 17.2 nM 7.76
CHEMBL1269596 IC50 = 19.8 nM 7.70
CHEMBL1269582 IC50 = 20.6 nM 7.69
CHEMBL1269584 IC50 = 24.2 nM 7.62
CHEMBL1269589 IC50 = 25.2 nM 7.60
CHEMBL1269580 IC50 = 26.1 nM 7.58
CHEMBL1269591 IC50 = 28.9 nM 7.54
CHEMBL1269581 IC50 = 30.5 nM 7.52
CHEMBL1269594 IC50 = 55.9 nM 7.25
CHEMBL1269590 IC50 = 59.5 nM 7.22
CHEMBL1269579 IC50 = 66.8 nM 7.17
CHEMBL1269585 IC50 = 79.7 nM 7.10
CHEMBL1269592 IC50 = 97.1 nM 7.01
CHEMBL1269586 IC50 = 151.0 nM 6.82
CHEMBL1269593 IC50 = 158.0 nM 6.80
CHEMBL1269587 IC50 = 1583.0 nM 5.80