Confirm a stable target identifier before relying on this context across project surfaces.
CHEMBL397 Target Snapshot
Jurkat · CELL-LINE · Homo sapiens
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As of 2026-09-13Confirm a stable target identifier before relying on this context across project surfaces.
Jurkat
Review this target as Jurkat.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Jurkat as ChEMBL target CHEMBL397. Disease framing currently uses the Open Targets-ready proxy contract.
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Open Review-ready CardBasic Information
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| Preferred Name | Jurkat |
| Target Type | CELL-LINE |
| Organism | Homo sapiens |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
How to read this target
Review this target as Jurkat.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4466320 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL4472466 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL4636420 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL1800843 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL5421145 | 10.05 | IC50 | 0.09 | Preclinical |
| CHEMBL4071326 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL5559818 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL5557704 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL1800842 | 9.85 | IC50 | 0.14 | Preclinical |
| CHEMBL5428441 | 9.82 | IC50 | 0.15 | Preclinical |
pChEMBL Value Distribution
Approved Drugs
Assay Landscape
Functional — 2,411 assays, 3,442 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2,404 | 3,442 | 5.8 |
| organism-based format | 7 | 0 | — |
ADME — 100 assays, 201 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 100 | 201 | 5.1 |
Toxicity — 28 assays, 64 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 28 | 64 | 6.2 |
Binding — 5 assays, 0 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 0 | — |
Unassigned — 5 assays, 0 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 0 | — |