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Target Snapshot

CHEMBL397 Target Snapshot

Jurkat · CELL-LINE · Homo sapiens

7,085Compounds
2,547Assays
62Approved Drugs
5,713.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Jurkat as ChEMBL target CHEMBL397. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Jurkat
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL397
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Jurkat still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelJurkat
UniProt AccessionN/A

Jurkat

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Jurkat.

Review nameJurkat
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

62
Approved
13
Phase III
19
Phase II
12
Phase I
Assay Mix

Activity Type Distribution

IC504,755.0
KI19.0
EC50928.0
KD11.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4466320 11.0 IC50 0.01 Preclinical
CHEMBL4472466 10.7 IC50 0.02 Preclinical
CHEMBL4636420 10.3 IC50 0.05 Preclinical
CHEMBL1800843 10.22 IC50 0.06 Preclinical
CHEMBL5421145 10.05 IC50 0.09 Preclinical
CHEMBL4071326 10.0 IC50 0.1 Preclinical
CHEMBL5559818 10.0 IC50 0.1 Preclinical
CHEMBL5557704 10.0 IC50 0.1 Preclinical
CHEMBL1800842 9.85 IC50 0.14 Preclinical
CHEMBL5428441 9.82 IC50 0.15 Preclinical
Distribution

pChEMBL Value Distribution

819
5.0
639
5.5
566
6.0
349
6.5
228
7.0
168
7.5
124
8.0
31
8.5
33
9.0
11
9.5
pChEMBL
Approved Drugs

Approved Drugs

FEDRATINIB
CHEMBL1287853
Approved 2019
SELINEXOR
CHEMBL3545185
Approved 2019
BELINOSTAT
CHEMBL408513
Approved 2014
PONATINIB
CHEMBL1171837
Approved 2012
PAZOPANIB
CHEMBL477772
Approved 2009
VORINOSTAT
CHEMBL98
Approved 2006
NELARABINE
CHEMBL1201112
Approved 2005
MYCOPHENOLIC ACID
CHEMBL866
Approved 2004
TOPOTECAN HYDROCHLORIDE
CHEMBL1607
Approved 1996
GEMCITABINE
CHEMBL888
Approved 1996
TACROLIMUS ANHYDROUS
CHEMBL269732
Approved 1994
CLADRIBINE
CHEMBL1619
Approved 1993
PACLITAXEL
CHEMBL428647
Approved 1992
PODOFILOX
CHEMBL61
Approved 1990
AMSACRINE
CHEMBL43
Approved 1987
ZIDOVUDINE
CHEMBL129
Approved 1987
CYCLOSPORINE
CHEMBL160
Approved 1983
ETOPOSIDE
CHEMBL44657
Approved 1983
NICLOSAMIDE
CHEMBL1448
Approved 1982
MITOMYCIN
CHEMBL105
Approved 1981
DAUNORUBICIN
CHEMBL178
Approved 1979
SINCALIDE
CHEMBL1121
Approved 1976
DOXORUBICIN
CHEMBL53463
Approved 1974
FLOXURIDINE
CHEMBL917
Approved 1970
DACTINOMYCIN
CHEMBL1554
Approved 1964
COLCHICINE
CHEMBL107
Approved 1961
Assay Landscape

Assay Landscape

2,549
Total Assays
3,442
Tested Compounds
5
Assay Types
Functional — 2,411 assays, 3,442 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2,404 3,442 5.8
organism-based format 7 0
ADME — 100 assays, 201 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 100 201 5.1
Toxicity — 28 assays, 64 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 28 64 6.2
Binding — 5 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 0
Unassigned — 5 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine