Review anchor
Jurkat
CELL-LINE · Homo sapiens
As of 2026-09-13
Evidence Snapshot
Jurkat
CHEMBL397
CELL-LINE
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Jurkat as ChEMBL target CHEMBL397. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL397
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Jurkat matters
Jurkat is reviewed as Jurkat; the current evidence base includes 62 approved drugs, 7085 compounds, and 2547 assays, with lead potency reaching pChEMBL 11.0.
Protein context
Jurkat
Jurkat
Review this target as Jurkat.
Protein source · UniProt accession via ChEMBL component mappingDisease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 62 approved drugs, 7085 compounds, and 2547 assays for this target. The dominant activity type is IC50. CHEMBL4466320 is the current potency anchor at pChEMBL 11.0.
Use CHEMBL4466320 as the tractability anchor when discussing potency (pChEMBL 11.0).
Activity source · ChEMBL 36 via Core Engine
62 approved
pChEMBL 11.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Jurkat matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
7085
Total Compounds
2547
Total Assays
62
Approved Drugs
IC50: 4755.0, KI: 19.0, EC50: 928.0, KD: 11.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL4466320
|
11.0 | IC50 | — |
|
|
No preferred name
CHEMBL4472466
|
10.7 | IC50 | — |
|
|
No preferred name
CHEMBL4636420
|
10.3 | IC50 | — |
|
|
No preferred name
CHEMBL1800843
|
10.2 | IC50 | — |
|
|
No preferred name
CHEMBL5421145
|
10.1 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
FEDRATINIB
CHEMBL1287853
|
2019 |
|
|
SELINEXOR
CHEMBL3545185
|
2019 |
|
|
BELINOSTAT
CHEMBL408513
|
2014 |
|
|
PONATINIB
CHEMBL1171837
|
2012 |
|
|
PAZOPANIB
CHEMBL477772
|
2009 |
|
|
VORINOSTAT
CHEMBL98
|
2006 |
|
|
NELARABINE
CHEMBL1201112
|
2005 |
|
|
MYCOPHENOLIC ACID
CHEMBL866
|
2004 |
|
|
TOPOTECAN HYDROCHLORIDE
CHEMBL1607
|
1996 |
|
|
GEMCITABINE
CHEMBL888
|
1996 |
|
|
TACROLIMUS ANHYDROUS
CHEMBL269732
|
1994 |
|
|
CLADRIBINE
CHEMBL1619
|
1993 |
|
|
PACLITAXEL
CHEMBL428647
|
1992 |
|
|
PODOFILOX
CHEMBL61
|
1990 |
|
|
AMSACRINE
CHEMBL43
|
1987 |
|
|
ZIDOVUDINE
CHEMBL129
|
1987 |
|
|
CYCLOSPORINE
CHEMBL160
|
1983 |
|
|
ETOPOSIDE
CHEMBL44657
|
1983 |
|
|
NICLOSAMIDE
CHEMBL1448
|
1982 |
|
|
MITOMYCIN
CHEMBL105
|
1981 |
|
|
DAUNORUBICIN
CHEMBL178
|
1979 |
|
|
SINCALIDE
CHEMBL1121
|
1976 |
|
|
DOXORUBICIN
CHEMBL53463
|
1974 |
|
|
FLOXURIDINE
CHEMBL917
|
1970 |
|
|
DACTINOMYCIN
CHEMBL1554
|
1964 |
|
|
COLCHICINE
CHEMBL107
|
1961 |
Source Header