Assay Detail
Binding
CHEMBL3389567
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Binding affinity to human cyclophilin F by surface plasmon resonance method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (CHEMBL3325306) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.74 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3344501 | — | — | 1 | 9.05 |
| CHEMBL1651956 | ALISPORIVIR | 3.0 | 1 | 9.00 |
| CHEMBL1269597 | SCY 635 | 2.0 | 1 | 8.51 |
| CHEMBL1688529 | NIM811 | 2.0 | 1 | 8.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3344501 | — | Kd | = | 0.9 | nM | 9.05 |
| CHEMBL1651956 | ALISPORIVIR | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL1269597 | SCY 635 | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL1688529 | NIM811 | Kd | = | 4.2 | nM | 8.38 |