Assay Detail
Binding
CHEMBL1216941
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Inhibition of p110beta
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.33 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1213118 | — | — | 1 | 8.05 |
| CHEMBL1213117 | — | — | 1 | 7.64 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 7.48 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 7.36 |
| CHEMBL1213084 | — | — | 1 | 6.66 |
| CHEMBL1213120 | — | — | 1 | 6.50 |
| CHEMBL1213119 | — | — | 1 | 6.18 |
| CHEMBL1213085 | — | — | 1 | 6.16 |
| CHEMBL1213116 | — | — | 1 | 6.12 |
| CHEMBL1213169 | — | — | 1 | 5.37 |
| CHEMBL1213168 | — | — | 1 | 5.00 |
| CHEMBL1213083 | — | — | 1 | 4.96 |
| CHEMBL1213082 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1213118 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1213117 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1213084 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1213120 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL1213119 | — | IC50 | = | 664.0 | nM | 6.18 |
| CHEMBL1213085 | — | IC50 | = | 697.0 | nM | 6.16 |
| CHEMBL1213116 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1213169 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL1213168 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1213083 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1213082 | — | IC50 | = | 16000.0 | nM | 4.80 |