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Assay Detail

CHEMBL1216985

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Binding
Inhibition of human HDAC4
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase 4 (CHEMBL3524)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Chemical phylogenetics of histone deacetylases.
Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R.
Nat Chem Biol (2010) 6 : 238 -243
PubMed 20139990 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 5.91 7.69

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL343448 ROMIDEPSIN 4.0 1 7.69
CHEMBL408513 BELINOSTAT 4.0 1 6.42
CHEMBL99 TRICHOSTATIN 1.0 1 6.40
CHEMBL483254 PANOBINOSTAT 4.0 1 6.26
CHEMBL1213457 1 6.02
CHEMBL1213492 GIVINOSTAT 4.0 1 5.98
CHEMBL356066 DACINOSTAT 2.0 1 5.65
CHEMBL96051 SCRIPTAID 1 5.12
CHEMBL356769 TUBACIN 1 4.77
CHEMBL1213458 1 4.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL343448 ROMIDEPSIN Ki = 20.5 nM 7.69
CHEMBL408513 BELINOSTAT Ki = 380.0 nM 6.42
CHEMBL99 TRICHOSTATIN Ki = 400.0 nM 6.40
CHEMBL483254 PANOBINOSTAT Ki = 550.0 nM 6.26
CHEMBL1213457 Ki = 950.0 nM 6.02
CHEMBL1213492 GIVINOSTAT Ki = 1050.0 nM 5.98
CHEMBL356066 DACINOSTAT Ki = 2250.0 nM 5.65
CHEMBL96051 SCRIPTAID Ki = 7500.0 nM 5.12
CHEMBL356769 TUBACIN Ki = 17000.0 nM 4.77
CHEMBL1213458 Ki = 17500.0 nM 4.76