Assay Detail
Binding
CHEMBL1216986
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HDAC5
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical phylogenetics of histone deacetylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.96 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 7.10 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 6.76 |
| CHEMBL1213457 | — | — | 1 | 6.75 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 6.58 |
| CHEMBL356066 | DACINOSTAT | 2.0 | 1 | 6.38 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 6.26 |
| CHEMBL1213492 | GIVINOSTAT | 4.0 | 1 | 6.22 |
| CHEMBL96051 | SCRIPTAID | — | 1 | 6.00 |
| CHEMBL356769 | TUBACIN | — | 1 | 5.82 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.44 |
| CHEMBL353581 | PYROXAMIDE | 1.0 | 1 | 5.32 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | — | 1 | 5.02 |
| CHEMBL1213458 | — | — | 1 | 4.94 |
| CHEMBL55895 | PHENYLBUTYRYLHYDROXAMIC ACID | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL408513 | BELINOSTAT | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL1213457 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL99 | TRICHOSTATIN | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL356066 | DACINOSTAT | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL343448 | ROMIDEPSIN | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL1213492 | GIVINOSTAT | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL96051 | SCRIPTAID | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL356769 | TUBACIN | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL98 | VORINOSTAT | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL353581 | PYROXAMIDE | Ki | = | 4750.0 | nM | 5.32 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL1213458 | — | Ki | = | 11500.0 | nM | 4.94 |
| CHEMBL55895 | PHENYLBUTYRYLHYDROXAMIC ACID | Ki | = | 16000.0 | nM | 4.80 |