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Assay Detail

CHEMBL1217009

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Functional
Antimicrobial activity against Leishmania donovani
ChEMBL ↗
287
Total Activities
287
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania donovani (CHEMBL367) ↗
Type ORGANISM
Organism Leishmania donovani

Publication

Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Prado-Prado FJ, García-Mera X, González-Díaz H.
Bioorg Med Chem (2010) 18 : 2225 -2231
PubMed 20185316 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 287 4.72 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL55 PENTAMIDINE 4.0 1 6.00
CHEMBL1214186 SINEFUNGIN 2.0 1 6.00
CHEMBL1213587 — — 1 6.00
CHEMBL335031 — — 1 5.70
CHEMBL134674 — — 1 5.70
CHEMBL157101 KETOCONAZOLE 4.0 1 5.70
CHEMBL132641 — — 1 5.52
CHEMBL55225 — — 1 5.52
CHEMBL1213178 ALLOPURINOL RIBOSIDE — 1 5.40
CHEMBL1213548 — — 1 5.40
CHEMBL135406 — — 1 5.40
CHEMBL298564 — — 1 5.40
CHEMBL51746 — — 1 5.30
CHEMBL53153 — — 1 5.30
CHEMBL130225 — — 1 5.30
CHEMBL136952 — — 1 5.30
CHEMBL98210 — — 1 5.30
CHEMBL53033 — — 1 5.22
CHEMBL1213547 — — 1 5.10
CHEMBL298774 — — 1 5.10
CHEMBL1213503 — — 1 5.05
CHEMBL99717 — — 1 4.96
CHEMBL337455 — — 1 4.96
CHEMBL53698 — — 1 4.96
CHEMBL1213502 — — 1 4.92
CHEMBL1213549 — — 1 4.92
CHEMBL1213550 — — 1 4.92
CHEMBL99340 — — 1 4.89
CHEMBL298557 — — 1 4.89
CHEMBL1213590 — — 1 4.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1214186 SINEFUNGIN IC50 = 1000.0 nM 6.00
CHEMBL1213587 — IC50 = 1000.0 nM 6.00
CHEMBL55 PENTAMIDINE IC50 = 1000.0 nM 6.00
CHEMBL157101 KETOCONAZOLE IC50 = 2000.0 nM 5.70
CHEMBL335031 — IC50 = 2000.0 nM 5.70
CHEMBL134674 — IC50 = 2000.0 nM 5.70
CHEMBL132641 — IC50 = 3000.0 nM 5.52
CHEMBL55225 — IC50 = 3000.0 nM 5.52
CHEMBL1213178 ALLOPURINOL RIBOSIDE IC50 = 4000.0 nM 5.40
CHEMBL1213548 — IC50 = 4000.0 nM 5.40
CHEMBL298564 — IC50 = 4000.0 nM 5.40
CHEMBL135406 — IC50 = 4000.0 nM 5.40
CHEMBL51746 — IC50 = 5000.0 nM 5.30
CHEMBL53153 — IC50 = 5000.0 nM 5.30
CHEMBL130225 — IC50 = 5000.0 nM 5.30
CHEMBL136952 — IC50 = 5000.0 nM 5.30
CHEMBL98210 — IC50 = 5000.0 nM 5.30
CHEMBL53033 — IC50 = 6000.0 nM 5.22
CHEMBL298774 — IC50 = 8000.0 nM 5.10
CHEMBL1213547 — IC50 = 8000.0 nM 5.10
CHEMBL1213503 — IC50 = 9000.0 nM 5.05
CHEMBL53698 — IC50 = 11000.0 nM 4.96
CHEMBL337455 — IC50 = 11000.0 nM 4.96
CHEMBL99717 — IC50 = 11000.0 nM 4.96
CHEMBL1213550 — IC50 = 12000.0 nM 4.92
CHEMBL1213549 — IC50 = 12000.0 nM 4.92
CHEMBL1213502 — IC50 = 12000.0 nM 4.92
CHEMBL298557 — IC50 = 13000.0 nM 4.89
CHEMBL99340 — IC50 = 13000.0 nM 4.89
CHEMBL1213590 — IC50 = 14000.0 nM 4.85
CHEMBL1213464 — IC50 = 17000.0 nM 4.77
CHEMBL335105 — IC50 = 17000.0 nM 4.77
CHEMBL1213501 — IC50 = 18000.0 nM 4.75
CHEMBL298397 — IC50 = 21000.0 nM 4.68
CHEMBL52597 — IC50 = 23000.0 nM 4.64
CHEMBL335298 — IC50 = 26000.0 nM 4.58
CHEMBL52127 — IC50 = 26000.0 nM 4.58
CHEMBL299079 — IC50 = 27000.0 nM 4.57
CHEMBL318045 — IC50 = 31000.0 nM 4.51
CHEMBL52182 — IC50 = 32000.0 nM 4.50
CHEMBL54952 — IC50 = 32000.0 nM 4.50
CHEMBL336114 — IC50 = 33000.0 nM 4.48
CHEMBL100210 — IC50 = 36000.0 nM 4.44
CHEMBL133958 — IC50 = 38000.0 nM 4.42
CHEMBL317528 — IC50 = 41000.0 nM 4.39
CHEMBL1213746 — IC50 = 43000.0 nM 4.37
CHEMBL54012 — IC50 = 43000.0 nM 4.37
CHEMBL298362 — IC50 = 43000.0 nM 4.37
CHEMBL135194 — IC50 = 44000.0 nM 4.36
CHEMBL301267 ARTEMOTIL IC50 = 45000.0 nM 4.35