Assay Detail
Binding
CHEMBL1217104
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Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.62 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.77 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.64 |
| CHEMBL1214194 | — | — | 1 | 6.24 |
| CHEMBL1214195 | — | — | 1 | 6.21 |
| CHEMBL119296 | — | — | 1 | 6.20 |
| CHEMBL303004 | — | — | 1 | 6.16 |
| CHEMBL25101 | — | — | 1 | 4.99 |
| CHEMBL19612 | SPERMIDINE | 3.0 | 1 | 4.94 |
| CHEMBL303429 | — | — | 1 | 4.94 |
| CHEMBL1214248 | — | — | 1 | 4.90 |
| CHEMBL23194 | SPERMINE | 0.5 | 1 | 4.65 |
| CHEMBL609 | TRIENTINE | 4.0 | 1 | 4.28 |
| CHEMBL1214193 | — | — | 1 | 4.18 |
| CHEMBL1212954 | — | — | 1 | - |
| CHEMBL209126 | — | — | 1 | - |
| CHEMBL1214249 | — | — | 1 | - |
| CHEMBL1214320 | — | — | 1 | - |
| CHEMBL1214321 | — | — | 1 | - |
| CHEMBL1214322 | — | — | 1 | - |
| CHEMBL1214323 | — | — | 1 | - |
| CHEMBL14060 | PHENOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL1214194 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL1214195 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL119296 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL303004 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL25101 | — | Ki | = | 10200.0 | nM | 4.99 |
| CHEMBL19612 | SPERMIDINE | Ki | = | 11600.0 | nM | 4.94 |
| CHEMBL303429 | — | Ki | = | 11500.0 | nM | 4.94 |
| CHEMBL1214248 | — | Ki | = | 12600.0 | nM | 4.90 |
| CHEMBL23194 | SPERMINE | Ki | = | 22600.0 | nM | 4.65 |
| CHEMBL609 | TRIENTINE | Ki | = | 52000.0 | nM | 4.28 |
| CHEMBL1214193 | — | Ki | = | 66000.0 | nM | 4.18 |
| CHEMBL1212954 | — | Ki | = | 179000.0 | nM | - |
| CHEMBL209126 | — | Ki | = | 136000.0 | nM | - |
| CHEMBL1214249 | — | Ki | = | 131000.0 | nM | - |
| CHEMBL1214320 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL1214321 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL1214322 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL1214323 | — | Ki | = | 127000.0 | nM | - |
| CHEMBL14060 | PHENOL | Ki | > | 500000.0 | nM | - |