Assay Detail
Binding
CHEMBL1217106
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.63 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.14 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.02 |
| CHEMBL1214195 | — | — | 1 | 6.24 |
| CHEMBL119296 | — | — | 1 | 6.19 |
| CHEMBL303004 | — | — | 1 | 6.18 |
| CHEMBL1214194 | — | — | 1 | 6.12 |
| CHEMBL25101 | — | — | 1 | 6.11 |
| CHEMBL19612 | SPERMIDINE | 3.0 | 1 | 5.00 |
| CHEMBL14060 | PHENOL | 4.0 | 1 | 4.98 |
| CHEMBL609 | TRIENTINE | 4.0 | 1 | 4.23 |
| CHEMBL1214193 | — | — | 1 | 4.18 |
| CHEMBL23194 | SPERMINE | 0.5 | 1 | 4.13 |
| CHEMBL1212954 | — | — | 1 | - |
| CHEMBL209126 | — | — | 1 | - |
| CHEMBL1214249 | — | — | 1 | - |
| CHEMBL1214320 | — | — | 1 | - |
| CHEMBL1214321 | — | — | 1 | - |
| CHEMBL1214322 | — | — | 1 | - |
| CHEMBL1214323 | — | — | 1 | - |
| CHEMBL1214248 | — | — | 1 | - |
| CHEMBL303429 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL1214195 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL119296 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL303004 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL1214194 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL25101 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL19612 | SPERMIDINE | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL14060 | PHENOL | Ki | = | 10500.0 | nM | 4.98 |
| CHEMBL609 | TRIENTINE | Ki | = | 59000.0 | nM | 4.23 |
| CHEMBL1214193 | — | Ki | = | 66000.0 | nM | 4.18 |
| CHEMBL23194 | SPERMINE | Ki | = | 74000.0 | nM | 4.13 |
| CHEMBL1212954 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL209126 | — | Ki | = | 236000.0 | nM | - |
| CHEMBL1214249 | — | Ki | = | 104000.0 | nM | - |
| CHEMBL1214320 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL1214321 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL1214322 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL1214323 | — | Ki | = | 110000.0 | nM | - |
| CHEMBL1214248 | — | Ki | = | 110000.0 | nM | - |
| CHEMBL303429 | — | Ki | = | 105000.0 | nM | - |