Assay Detail
Functional
CHEMBL1217128
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human KBV1 cells overexpressing MDR1 after 72 hrs by Alamar blue assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB-V1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.07 | 5.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 5.69 |
| CHEMBL1213890 | — | — | 1 | 5.68 |
| CHEMBL394880 | DIMETHYLENASTRON | — | 1 | 4.91 |
| CHEMBL236789 | MONASTROL | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | EC50 | = | 2037.0 | nM | 5.69 |
| CHEMBL1213890 | — | EC50 | = | 2084.0 | nM | 5.68 |
| CHEMBL394880 | DIMETHYLENASTRON | EC50 | = | 12303.0 | nM | 4.91 |
| CHEMBL236789 | MONASTROL | EC50 | = | 99083.0 | nM | 4.00 |