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Assay Detail

CHEMBL1217287

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Bacillus stearothermophilus alpha glucosidase-4
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Geobacillus stearothermophilus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Proanthocyanidins from the leaves of Machilus philippinensis.
Lin HC, Lee SS.
J Nat Prod (2010) 73 : 1375 -1380
PubMed 20568785 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 5.17 7.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL404271 ACARBOSE 4.0 1 7.31
CHEMBL1213875 AESCULTITANNIN B 1 5.46
CHEMBL1213877 1 4.98
CHEMBL1213880 1 4.74
CHEMBL1213879 1 4.50
CHEMBL1213876 CINNAMTANNIN D1 1 4.03
CHEMBL583912 (-)-EPICATECHIN 2.0 1 -
CHEMBL540956 CINNAMTANNIN B1 1 -
CHEMBL1213878 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL404271 ACARBOSE IC50 = 49.0 nM 7.31
CHEMBL1213875 AESCULTITANNIN B IC50 = 3500.0 nM 5.46
CHEMBL1213877 IC50 = 10500.0 nM 4.98
CHEMBL1213880 IC50 = 18400.0 nM 4.74
CHEMBL1213879 IC50 = 31300.0 nM 4.50
CHEMBL1213876 CINNAMTANNIN D1 IC50 = 92900.0 nM 4.03
CHEMBL583912 (-)-EPICATECHIN IC50 > 100000.0 nM -
CHEMBL540956 CINNAMTANNIN B1 IC50 > 100000.0 nM -
CHEMBL1213878 IC50 > 100000.0 nM -