Assay Detail
Binding
CHEMBL1217375
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from mu opioid receptor in Sprague-Dawley rat brain P2 synaptosomal membrane
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.77 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109390 | — | — | 1 | 9.30 |
| CHEMBL1213989 | — | — | 1 | 8.78 |
| CHEMBL1213991 | — | — | 1 | 8.39 |
| CHEMBL442577 | — | — | 1 | 7.27 |
| CHEMBL1213987 | — | — | 1 | 7.26 |
| CHEMBL1213988 | — | — | 1 | 7.17 |
| CHEMBL1213990 | — | — | 1 | 6.81 |
| CHEMBL1213938 | — | — | 1 | 6.65 |
| CHEMBL1214117 | — | — | 1 | 6.29 |
| CHEMBL1214050 | — | — | 1 | 6.24 |
| CHEMBL1214118 | — | — | 1 | 6.22 |
| CHEMBL296603 | DELTORPHINE II | — | 1 | 6.20 |
| CHEMBL1213939 | — | — | 1 | 6.17 |
| CHEMBL1213992 | — | — | 1 | 5.99 |
| CHEMBL1212952 | — | — | 1 | 5.91 |
| CHEMBL1214119 | — | — | 1 | 5.84 |
| CHEMBL1214048 | — | — | 1 | 5.78 |
| CHEMBL1214049 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109390 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1213989 | — | Ki | = | 1.68 | nM | 8.78 |
| CHEMBL1213991 | — | Ki | = | 4.05 | nM | 8.39 |
| CHEMBL442577 | — | Ki | = | 53.9 | nM | 7.27 |
| CHEMBL1213987 | — | Ki | = | 54.5 | nM | 7.26 |
| CHEMBL1213988 | — | Ki | = | 66.9 | nM | 7.17 |
| CHEMBL1213990 | — | Ki | = | 154.3 | nM | 6.81 |
| CHEMBL1213938 | — | Ki | = | 225.1 | nM | 6.65 |
| CHEMBL1214117 | — | Ki | = | 511.4 | nM | 6.29 |
| CHEMBL1214050 | — | Ki | = | 573.3 | nM | 6.24 |
| CHEMBL1214118 | — | Ki | = | 596.4 | nM | 6.22 |
| CHEMBL296603 | DELTORPHINE II | Ki | = | 638.0 | nM | 6.20 |
| CHEMBL1213939 | — | Ki | = | 683.9 | nM | 6.17 |
| CHEMBL1213992 | — | Ki | = | 1029.0 | nM | 5.99 |
| CHEMBL1212952 | — | Ki | = | 1234.0 | nM | 5.91 |
| CHEMBL1214119 | — | Ki | = | 1451.0 | nM | 5.84 |
| CHEMBL1214048 | — | Ki | = | 1649.0 | nM | 5.78 |
| CHEMBL1214049 | — | Ki | = | 2435.0 | nM | 5.61 |