Assay Detail
Binding
CHEMBL1217615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]substance P frome rat NK2 receptor
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.62 | 8.35 |
| IC50 | 6 | 7.05 | 7.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1214025 | — | — | 2 | 8.35 |
| CHEMBL507340 | — | — | 2 | 8.14 |
| CHEMBL1214024 | — | — | 2 | 8.00 |
| CHEMBL1214027 | — | — | 2 | 7.58 |
| CHEMBL22870 | L-732138 | — | 2 | 6.87 |
| CHEMBL1214026 | — | — | 2 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1214025 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL507340 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL1214024 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1214025 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL507340 | — | IC50 | = | 24.55 | nM | 7.61 |
| CHEMBL1214027 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL1214024 | — | IC50 | = | 41.69 | nM | 7.38 |
| CHEMBL1214027 | — | IC50 | = | 104.71 | nM | 6.98 |
| CHEMBL22870 | L-732138 | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL1214026 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL22870 | L-732138 | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL1214026 | — | IC50 | = | 660.69 | nM | 6.18 |