Assay Detail
Binding
CHEMBL1218399
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]IP3 from full-length rat recombinant IP3R1 expressed in chicken DT40 cells by equilibrium competitive binding assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | DT40 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (CHEMBL2804) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthetic partial agonists reveal key steps in IP3 receptor activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 8.47 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1213158 | — | — | 1 | 9.35 |
| CHEMBL1213159 | — | — | 1 | 9.07 |
| CHEMBL1212943 | — | — | 1 | 9.05 |
| CHEMBL1213160 | — | — | 1 | 9.05 |
| CHEMBL204385 | ADENOPHOSTIN A | — | 1 | 8.90 |
| CHEMBL1213163 | — | — | 1 | 8.12 |
| CHEMBL1213161 | — | — | 1 | 8.11 |
| CHEMBL279107 | INS(1,4,5)P3 | — | 1 | 7.90 |
| CHEMBL1213201 | — | — | 1 | 7.77 |
| CHEMBL1213202 | — | — | 1 | 7.36 |
| CHEMBL1213162 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1213158 | — | Kd | = | 0.45 | nM | 9.35 |
| CHEMBL1213159 | — | Kd | = | 0.86 | nM | 9.07 |
| CHEMBL1212943 | — | Kd | = | 0.9 | nM | 9.05 |
| CHEMBL1213160 | — | Kd | = | 0.89 | nM | 9.05 |
| CHEMBL204385 | ADENOPHOSTIN A | Kd | = | 1.26 | nM | 8.90 |
| CHEMBL1213163 | — | Kd | = | 7.62 | nM | 8.12 |
| CHEMBL1213161 | — | Kd | = | 7.82 | nM | 8.11 |
| CHEMBL279107 | INS(1,4,5)P3 | Kd | = | 12.5 | nM | 7.90 |
| CHEMBL1213201 | — | Kd | = | 17.1 | nM | 7.77 |
| CHEMBL1213202 | — | Kd | = | 43.6 | nM | 7.36 |
| CHEMBL1213162 | — | Kd | - | — | - |