Assay Detail
Binding
CHEMBL1218404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]IP3 from rat recombinant IP3R1 N-terminal residue (1-604) R36E mutant expressed in chicken DT40 cells by equilibrium competitive binding assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | DT40 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (CHEMBL2804) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthetic partial agonists reveal key steps in IP3 receptor activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 9.37 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1213158 | — | — | 1 | 9.40 |
| CHEMBL279107 | INS(1,4,5)P3 | — | 1 | 9.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1213158 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL279107 | INS(1,4,5)P3 | Kd | = | 0.46 | nM | 9.34 |