Assay Detail
Functional
CHEMBL1218409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat recombinant IP3R1 R36E mutant expressed in chicken DT40 cells assessed as calcium release from intracellular stores
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | DT40 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (CHEMBL2804) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthetic partial agonists reveal key steps in IP3 receptor activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.60 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1213158 | — | — | 1 | 7.80 |
| CHEMBL279107 | INS(1,4,5)P3 | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1213158 | — | EC50 | = | 15.8 | nM | 7.80 |
| CHEMBL279107 | INS(1,4,5)P3 | EC50 | = | 40.8 | nM | 7.39 |