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Assay Detail

CHEMBL1218939

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assay at 50 uM
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Hematopoietic prostaglandin D synthase (CHEMBL5879)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases.
Christ AN, Labzin L, Bourne GT, Fukunishi H, Weber JE, Sweet MJ, Smythe ML, Flanagan JU.
J Med Chem (2010) 53 : 5536 -5548
PubMed 20684598 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 4.38 5.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1215231 1 5.75
CHEMBL1215368 1 5.29
CHEMBL1215229 1 5.20
CHEMBL1215228 1 4.97
CHEMBL1215445 1 4.83
CHEMBL1215161 1 4.70
CHEMBL1215447 1 4.69
CHEMBL1215444 1 4.61
CHEMBL1215158 1 4.59
CHEMBL1215514 1 4.42
CHEMBL1215230 1 4.36
CHEMBL1215515 1 4.27
CHEMBL1215372 1 4.27
CHEMBL1215232 1 4.24
CHEMBL1215371 1 4.24
CHEMBL1215446 1 4.21
CHEMBL1215295 1 4.17
CHEMBL1215162 1 4.15
CHEMBL1215298 1 4.14
CHEMBL1215294 1 4.13
CHEMBL574003 1 4.13
CHEMBL1215160 1 4.12
CHEMBL1215159 1 4.10
CHEMBL567059 1 4.08
CHEMBL1215296 1 4.05
CHEMBL1215369 1 4.05
CHEMBL1215297 1 4.04
CHEMBL1215370 1 4.04
CHEMBL258467 1 4.02
CHEMBL1215516 1 4.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1215231 IC50 = 1800.0 nM 5.75
CHEMBL1215368 IC50 = 5070.0 nM 5.29
CHEMBL1215229 IC50 = 6270.0 nM 5.20
CHEMBL1215228 IC50 = 10800.0 nM 4.97
CHEMBL1215445 IC50 = 14700.0 nM 4.83
CHEMBL1215161 IC50 = 19900.0 nM 4.70
CHEMBL1215447 IC50 = 20500.0 nM 4.69
CHEMBL1215444 IC50 = 24600.0 nM 4.61
CHEMBL1215158 IC50 = 25900.0 nM 4.59
CHEMBL1215514 IC50 = 38000.0 nM 4.42
CHEMBL1215230 IC50 = 43800.0 nM 4.36
CHEMBL1215515 IC50 = 54000.0 nM 4.27
CHEMBL1215372 IC50 = 53300.0 nM 4.27
CHEMBL1215232 IC50 = 57900.0 nM 4.24
CHEMBL1215371 IC50 = 57600.0 nM 4.24
CHEMBL1215446 IC50 = 61300.0 nM 4.21
CHEMBL1215295 IC50 = 66900.0 nM 4.17
CHEMBL1215162 IC50 = 71200.0 nM 4.15
CHEMBL1215298 IC50 = 72500.0 nM 4.14
CHEMBL1215294 IC50 = 73900.0 nM 4.13
CHEMBL574003 IC50 = 73900.0 nM 4.13
CHEMBL1215160 IC50 = 76400.0 nM 4.12
CHEMBL1215159 IC50 = 79200.0 nM 4.10
CHEMBL567059 IC50 = 83500.0 nM 4.08
CHEMBL1215296 IC50 = 89500.0 nM 4.05
CHEMBL1215369 IC50 = 88500.0 nM 4.05
CHEMBL1215297 IC50 = 91300.0 nM 4.04
CHEMBL1215370 IC50 = 91000.0 nM 4.04
CHEMBL258467 IC50 = 94600.0 nM 4.02
CHEMBL1215516 IC50 = 97000.0 nM 4.01
CHEMBL261777 IC50 = 97700.0 nM 4.01