Assay Detail
Binding
CHEMBL1218970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DPP4 assessed as Gly-Pro-pNA cleavage
34
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 8.73 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1215018 | — | — | 1 | 9.70 |
| CHEMBL1215088 | — | — | 1 | 9.52 |
| CHEMBL1214876 | — | — | 3 | 9.40 |
| CHEMBL1215087 | — | — | 1 | 9.30 |
| CHEMBL1215164 | — | — | 1 | 9.22 |
| CHEMBL1215236 | — | — | 1 | 9.15 |
| CHEMBL1215301 | — | — | 1 | 9.05 |
| CHEMBL1215089 | — | — | 1 | 9.05 |
| CHEMBL1215016 | — | — | 1 | 9.00 |
| CHEMBL1215233 | — | — | 1 | 8.96 |
| CHEMBL1215448 | — | — | 1 | 8.89 |
| CHEMBL1215376 | — | — | 1 | 8.85 |
| CHEMBL1215375 | — | — | 1 | 8.82 |
| CHEMBL1215165 | — | — | 1 | 8.74 |
| CHEMBL1215234 | — | — | 1 | 8.70 |
| CHEMBL1215163 | — | — | 1 | 8.70 |
| CHEMBL1214943 | — | — | 1 | 8.66 |
| CHEMBL1214877 | — | — | 1 | 8.62 |
| CHEMBL1215299 | — | — | 1 | 8.59 |
| CHEMBL1215167 | — | — | 1 | 8.59 |
| CHEMBL1214942 | — | — | 1 | 8.54 |
| CHEMBL1214944 | — | — | 1 | 8.51 |
| CHEMBL1215017 | — | — | 1 | 8.51 |
| CHEMBL1215235 | — | — | 1 | 8.49 |
| CHEMBL1215166 | — | — | 1 | 8.42 |
| CHEMBL1215300 | — | — | 1 | 8.40 |
| CHEMBL1215373 | — | — | 1 | 8.33 |
| CHEMBL1214945 | — | — | 1 | 8.30 |
| CHEMBL1215302 | — | — | 1 | 8.30 |
| CHEMBL1215374 | — | — | 1 | 8.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1215018 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL1215088 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL1214876 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL1215087 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1215164 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1214876 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL1215236 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL1215301 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL1215089 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL1215016 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1215233 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1215448 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL1215376 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL1215375 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL1215165 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL1215234 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1215163 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1214943 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL1214877 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1215299 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL1215167 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL1214942 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL1215017 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL1214944 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL1215235 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL1215166 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL1215300 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1215373 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL1215302 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL1214945 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL1215374 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL1215090 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL1215015 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL1214876 | — | Ki | = | 11.7 | nM | 7.93 |