Compound Detail
CHEMBL1215090
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Basic Information
| ChEMBL ID | CHEMBL1215090 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OWMXEZHWICQIBU-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
447.4
MW (Da)
4.49
ALogP
7
HBA
2
HBD
98.2
PSA (Ų)
0.48
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 8 CHEMBL4657 | Ki | 8.64 | 8.64 | 2.3 | 1 |
| Dipeptidyl peptidase 9 CHEMBL4793 | Ki | 8.46 | 8.46 | 3.5 | 1 |
| Dipeptidyl peptidase 4 CHEMBL284 | Ki | 8.18 | 8.18 | 6.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 8 | Ki | = | 2.3 | nM | 8.64 | Inhibition of human DPP8 | 20684603 |
| Dipeptidyl peptidase 9 | Ki | = | 3.5 | nM | 8.46 | Inhibition of human DPP9 | 20684603 |
| Dipeptidyl peptidase 4 | Ki | = | 6.6 | nM | 8.18 | Inhibition of human recombinant DPP4 assessed as Gly-Pro-pNA cleavage | 20684603 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20684603 | 10.1021/jm100634a | Dipeptidyl peptidase 4 | 1 |
| 20684603 | 10.1021/jm100634a | Dipeptidyl peptidase 8 | 1 |
| 20684603 | 10.1021/jm100634a | Dipeptidyl peptidase 9 | 1 |
Data from ChEMBL 36 via Core Engine