Assay Detail
Functional
CHEMBL1219212
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Cytotoxicity against human HCT116 cells by Alamar blue assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.95 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1215744 | — | — | 1 | 7.80 |
| CHEMBL1215677 | — | — | 1 | 7.68 |
| CHEMBL1215678 | — | — | 1 | 7.68 |
| CHEMBL1214677 | — | — | 1 | 7.68 |
| CHEMBL1215614 | — | — | 1 | 7.60 |
| CHEMBL1215741 | — | — | 1 | 7.55 |
| CHEMBL1215611 | — | — | 1 | 7.52 |
| CHEMBL1214678 | — | — | 1 | 7.52 |
| CHEMBL1215467 | — | — | 1 | 7.51 |
| CHEMBL1215676 | — | — | 1 | 7.50 |
| CHEMBL1214747 | — | — | 1 | 7.33 |
| CHEMBL1214827 | ONALESPIB | 2.0 | 1 | 7.32 |
| CHEMBL383824 | ALVESPIMYCIN | 2.0 | 1 | 7.30 |
| CHEMBL2448099 | — | — | 1 | 7.30 |
| CHEMBL1214749 | — | — | 1 | 7.17 |
| CHEMBL1215612 | — | — | 1 | 7.12 |
| CHEMBL1214750 | — | — | 1 | 7.10 |
| CHEMBL1215541 | — | — | 1 | 7.10 |
| CHEMBL1214679 | — | — | 1 | 7.10 |
| CHEMBL1215743 | — | — | 1 | 7.08 |
| CHEMBL1215613 | — | — | 1 | 7.05 |
| CHEMBL1215742 | — | — | 1 | 7.03 |
| CHEMBL1214746 | — | — | 1 | 7.02 |
| CHEMBL1214676 | — | — | 1 | 7.00 |
| CHEMBL1214748 | — | — | 1 | 6.89 |
| CHEMBL1215540 | — | — | 1 | 6.75 |
| CHEMBL1215675 | — | — | 1 | 6.70 |
| CHEMBL1215539 | — | — | 1 | 6.64 |
| CHEMBL1215542 | — | — | 1 | 6.54 |
| CHEMBL1215745 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1215744 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1215677 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1214677 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1215678 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1215614 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1215741 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1215611 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1214678 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1215467 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1215676 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1214747 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1214827 | ONALESPIB | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL383824 | ALVESPIMYCIN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2448099 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1214749 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1215612 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1214679 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1215541 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1214750 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1215743 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1215613 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1215742 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1214746 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL1214676 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1214748 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1215540 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1215675 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1215539 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1215542 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1215745 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1215468 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1215543 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1215538 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1215609 | — | IC50 | = | 30000.0 | nM | 4.52 |