Assay Detail
Binding
CHEMBL1219552
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Inhibition of Plasmodium falciparum HDAC1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.13 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1214760 | — | — | 1 | 8.00 |
| CHEMBL1214759 | — | — | 1 | 7.44 |
| CHEMBL1214761 | — | — | 1 | 7.40 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.89 |
| CHEMBL1214762 | — | — | 1 | 6.54 |
| CHEMBL1214763 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1214760 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1214759 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1214761 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1214762 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1214763 | — | IC50 | = | 304.0 | nM | 6.52 |