Assay Detail

CHEMBL1219829

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of PKD2 ( assessed as residual activity at 1 uM ) by TR-FRET assay

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Serine/threonine-protein kinase D2 (CHEMBL4900) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Serine/threonine-protein kinase D2 (CHEMBL4900) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Serine/threonine-protein kinase D2

CHEMBL4900

Anchored from Assay target.

Protein identity Serine/threonine-protein kinase D2

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Serine/threonine-protein kinase D2 (CHEMBL4900) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Identification of orally available naphthyridine protein kinase D inhibitors.

Meredith EL, Ardayfio O, Beattie K, Dobler MR, Enyedy I, Gaul C, Hosagrahara V, Jewell C, Koch K, Lee W, Lehmann H, McKinsey TA, Miranda K, Pagratis N, Pancost M, Patnaik A, Phan D, Plato C, Qian M, Rajaraman V, Rao C, Rozhitskaya O, Ruppen T, Shi J, Siska SJ, Springer C, van Eis M, Vega RB, von Matt A, Yang L, Yoon T, Zhang JH, Zhu N, Monovich LG.
J Med Chem (2010) 53 : 5400 -5421
PubMed 20684591 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Activity	2	-	-
IC50	2	8.25	8.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1214998	—	—	2	8.70
CHEMBL1214857	—	—	2	7.80

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1214998	—	IC50	=	2.0	nM	8.70
CHEMBL1214857	—	IC50	=	16.0	nM	7.80
CHEMBL1214857	—	Activity	=	7.0	%	-
CHEMBL1214998	—	Activity	=	2.0	%	-