Assay Detail
Binding
CHEMBL1219907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of MRP1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | MDCK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 4.52 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1097451 | — | — | 1 | 5.12 |
| CHEMBL1215644 | — | — | 1 | 4.92 |
| CHEMBL1215713 | — | — | 1 | 4.87 |
| CHEMBL299112 | — | — | 1 | 4.82 |
| CHEMBL1215576 | — | — | 1 | 4.53 |
| CHEMBL1215507 | — | — | 1 | 4.35 |
| CHEMBL1097450 | — | — | 1 | 4.34 |
| CHEMBL363325 | — | — | 1 | 4.31 |
| CHEMBL1215647 | — | — | 1 | 4.20 |
| CHEMBL1215577 | — | — | 1 | 4.14 |
| CHEMBL1215574 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1097451 | — | EC50 | = | 7610.0 | nM | 5.12 |
| CHEMBL1215644 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1215713 | — | EC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL299112 | — | EC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL1215576 | — | EC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL1215507 | — | EC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL1097450 | — | EC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL363325 | — | EC50 | = | 49100.0 | nM | 4.31 |
| CHEMBL1215647 | — | EC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL1215577 | — | EC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL1215574 | — | EC50 | = | 85800.0 | nM | 4.07 |