Assay Detail
Binding
CHEMBL1220906
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Binding affinity to N-terminal Shh by surface plasmon resonance assay
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 5.28 | 5.51 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473392 | ROBOTNIKININ | — | 1 | 5.51 |
| CHEMBL1213326 | — | — | 2 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473392 | ROBOTNIKININ | Kd | = | 3100.0 | nM | 5.51 |
| CHEMBL1213326 | — | Kd | = | 9000.0 | nM | 5.05 |
| CHEMBL1213326 | — | Activity | - | — | - |