Assay Detail
Binding
CHEMBL1225085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PMA-stimulated RSK2 phosphorylation in HEK293 cells after 1 hr by Western blotting analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A clickable inhibitor reveals context-dependent autoactivation of p90 RSK.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.91 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515414 | — | — | 1 | 6.82 |
| CHEMBL1221656 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515414 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1221656 | — | EC50 | = | 10000.0 | nM | 5.00 |