Assay Detail
Binding
CHEMBL1225633
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GDA by colorimetric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.41 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388596 | 2,6-DIAMINOPURINE | — | 1 | 5.73 |
| CHEMBL1424 | XANTHINE | — | 1 | 5.71 |
| CHEMBL1224659 | — | — | 1 | 5.46 |
| CHEMBL792 | URIC ACID | 2.0 | 1 | 5.36 |
| CHEMBL1610 | — | — | 1 | 5.35 |
| CHEMBL321248 | 7-METHYLXANTHINE | 2.0 | 1 | 5.26 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388596 | 2,6-DIAMINOPURINE | Ki | = | 1880.0 | nM | 5.73 |
| CHEMBL1424 | XANTHINE | Ki | = | 1960.0 | nM | 5.71 |
| CHEMBL1224659 | — | Ki | = | 3440.0 | nM | 5.46 |
| CHEMBL792 | URIC ACID | Ki | = | 4340.0 | nM | 5.36 |
| CHEMBL1610 | — | Ki | = | 4440.0 | nM | 5.35 |
| CHEMBL321248 | 7-METHYLXANTHINE | Ki | = | 5550.0 | nM | 5.26 |
| CHEMBL113 | CAFFEINE | Ki | = | 10200.0 | nM | 4.99 |