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Assay Detail

CHEMBL1225718

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Binding
Inhibition of human CYP1B1 by EROD assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cytochrome P450 1B1 (CHEMBL4878)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selective inhibition of methoxyflavonoids on human CYP1B1 activity.
Takemura H, Itoh T, Yamamoto K, Sakakibara H, Shimoi K.
Bioorg Med Chem (2010) 18 : 6310 -6315
PubMed 20696580 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.99 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL243664 ACACETIN 1 7.92
CHEMBL379064 ISORHAMNETIN 1 7.77
CHEMBL214321 CHRYSOERIOL 1 7.70
CHEMBL226034 TAMARIXETIN 1 7.70
CHEMBL117 CHRYSIN 1 7.62
CHEMBL28 APIGENIN 1 7.60
CHEMBL309490 GALANGIN 1 7.60
CHEMBL40919 KAEMPFERIDE 1 7.60
CHEMBL90568 DIOSMETIN 1 7.54
CHEMBL150 KAEMPFEROL 1.0 1 7.33
CHEMBL50 QUERCETIN 3.0 1 7.11
CHEMBL151 LUTEOLIN 2.0 1 7.10
CHEMBL399121 HESPERETIN 0.5 1 6.29
CHEMBL470266 ISOSAKUTANETIN 1 5.99
CHEMBL8996 ERIODICTYOL 1 5.89
CHEMBL399910 PINOCEMBRIN 2.0 1 5.78
CHEMBL490170 HOMOERIODICTYOL 1 5.76
CHEMBL9352 NARINGENIN 1 5.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL243664 ACACETIN IC50 = 12.0 nM 7.92
CHEMBL379064 ISORHAMNETIN IC50 = 17.0 nM 7.77
CHEMBL214321 CHRYSOERIOL IC50 = 20.0 nM 7.70
CHEMBL226034 TAMARIXETIN IC50 = 20.0 nM 7.70
CHEMBL117 CHRYSIN IC50 = 24.0 nM 7.62
CHEMBL28 APIGENIN IC50 = 25.0 nM 7.60
CHEMBL309490 GALANGIN IC50 = 25.0 nM 7.60
CHEMBL40919 KAEMPFERIDE IC50 = 25.0 nM 7.60
CHEMBL90568 DIOSMETIN IC50 = 29.0 nM 7.54
CHEMBL150 KAEMPFEROL IC50 = 47.0 nM 7.33
CHEMBL50 QUERCETIN IC50 = 77.0 nM 7.11
CHEMBL151 LUTEOLIN IC50 = 79.0 nM 7.10
CHEMBL399121 HESPERETIN IC50 = 511.0 nM 6.29
CHEMBL470266 ISOSAKUTANETIN IC50 = 1024.0 nM 5.99
CHEMBL8996 ERIODICTYOL IC50 = 1284.0 nM 5.89
CHEMBL399910 PINOCEMBRIN IC50 = 1679.0 nM 5.78
CHEMBL490170 HOMOERIODICTYOL IC50 = 1716.0 nM 5.76
CHEMBL9352 NARINGENIN IC50 = 3656.0 nM 5.44